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Publications

2014

  • Ju X, Ishikawa T, Naka K, Ito K, Ito Y, and Oshima M. Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cance cells. Cancer Sci, 2014 Jan 22. [Epub ahead of print].

2013

  • Oshima H, Ishikawa T, Yoshida GJ, Naoi K, Maeda Y, Naka K, Ju X, Yamada Y, Minamoto T, Mukaida N, Saya H, and Oshima M. TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. Oncogene, 2013 Aug 26. [Epub ahead of print].
  • Oshima H, and Oshima M. The role of PGE2-assocaited inflammatory responses in gastric cancer development. Semin Immunopathol, 35: 139-150, 2013.

2012

  • Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N, Dev A, Sievert W, Ooi CH, Ishikawa TO, Oshima H, Bhathal PS, Parker AE, Oshima M, Tan P, and Jenkins B. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell, 22: 466-478.
  • Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa TO, Oshima M. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene. 31: 3949-3960, 2012.
  • Oshima H, and Oshima M. The inflammatory network in the gastrointestinal microenvironment: Lessons from mouse models. J Gastroenterol. 47: 97-106, 2012.

2011

  • Oshima H, Hioki K, Popivanova BK, Oguma K, van Rooijen, N, Ishikawa T, and Oshima M. Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. Gastroenterology, 140: 596-607, 2011.
  • Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M. Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis. Cancer Sci, 102: 713-719, 2011.

2010

  • Oshima H, and Oshima M. Mouse models of gastric tumors: Wnt activation and PGE2 induction. Pathol Int, 60: 599-607, 2010.
  • Oguma K, Oshima H, and Oshima M. Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development. Future Oncology, 6: 515-526, 2010.

2009

  • Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Kotani H, Taketo MM, and Oshima M. Induction and downregulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology, 137: 1346-1357, 2009.
  • Oshima H, Itadani H, Kotani H, Taketo MM, and Oshima M. Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling. Cancer Res, 69: 2729-2733, 2009.
  • Oshima H, Oguma K, Du YC, and Oshima M. Prostaglandin E2, Wnt and BMP in gastric tumor mouse models. Cancer Sci, 100: 1779-1785, 2009. [Review]
  • Itadani H, Oshima H, Oshima, M, and Kotani H. Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer. BMC Genomics, 10: 615, 2009.

2008

  • Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM, and Oshima M. Activated macrophages promote Wnt signaling through tumor necrosis factor-α in gastric tumor cell. EMBO J, 27: 1671-1681, 2008.
  • Guo X, Oshima H, Kitamura T, Taketo MM, and Oshima M. Stromal fibroblasts activated by tumor cells promotes angiogenesis in mouse gastric cancer. J Biol Chem, 283: 19864-19871, 2008.
  • Piao YS, Du YC, Oshima H, Jin JC, Nomura M, Yoshimoto T, and Oshima M. Platelet 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency. Carcinogenesis, 29: 440-447, 2008.

2007

  • Oshima M, Suzuki H, Guo X, and Oshima H. Increased level of serum vascular endothelial growth factor by long-term exposure to hypergravity. Exp Anim, 56: 309-313, 2007.

2006

  • Oshima H, Matsunaga A, Fujumura T, Tsukamoto T, Taketo MM, and Oshima M. Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. Gastroenterology, 131: 1086-1095, 2006.
  • Oshima H, Taketo MM, and Oshima M. Destruction of pancreatic β-cells by transgenic induction of prostaglandin E2 in the islets. J Biol Chem, 281: 29330-29336, 2006.

2004

  • Oshima M, Oshima H, Matsunaga A, and Taketo MM. Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia (SPEM) caused by TNF-α-dependent inflammation in COX-2/mPGES-1 transgenic mice. Cancer Res, 65: 9147-9151, 2005.
  • Oshima H, Oshima M, Inaba K, and Taketo MM Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J, 23: 1669-1678, 2004.